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Scientists develop an innovative method for filling and sealing pleural cavities

University of Alicante and Albacete University Hospital Complex have designed a new easy-to-apply biocompatible polyurethane foam that prevents infections, bleeding, pain and fistulas in lung patients 




Alicante. Wednesday, 15 February 2017   

Researchers from the University of Alicante Adhesion and Adhesive Lab and the Thorax Surgery Service from the Albacete University Hospital Complex have developed a new method for filling and sealing pleural cavities. The process consists of injecting polyurethane foams into the lungs with a self-expanding and self-modelling capacity that replaces aggressive surgical and palliative treatments used so far.

This biocompatible material with very low risk of toxicity can be very easily applied through a small hole in the thorax. "Although there are different polyurethane foams for medical use, the innovative aspect of this method is that the foam is generated at the very moment it is placed in the cavity, mixtured with two liquid components", as explained by Professor of Inorganic Chemistry José Miguel Martín Martínez and chemist Alfonso de Lucas, both from the Adhesion and Adhesive Lab.

"When injected into the patient, the material foams touching the damp walls of surrounding tissues by creating a very compact surface area that acts as a mold that fully fills the entire volume of the pleural cavity. Therefore, the polyurethane foam adapts to the entire gap and prevents further complications in lung patients such as infections, inflammation, bleeding, pain or fistulas, according to the University of Alicante researchers.

Other than being a lightweight material, it does not adhere to the tissue walls and thus, prevents breakage problems if extraction is necessary. "As far as we know, there is no history of using polyurethane foams for filling the pleural cavity," José Miguel Martín stated. 


Effective and non-aggressive

There are several pathological processes where the pleural cavity presents air or other biological fluids such as pus or blood that are solved by simple drainage. However, especially after lung cancer surgery or severe lung infections, fluids can be accumulated with germs difficult to eradicate even using antibiotics or drainage. At this point, patients suffer progressive deterioration, pain, fever, choking and even death if not treated in time. "The filling and sealing of the pleural cavity with polyurethane foam would avoid liquid retention and would not leave gaps for the development of bacteria which means a definitive control of infection," as explained by Albacete University Hospital Complex thoracic surgeon Carlos Rombolá.

The treatments applied for the final sealing of chronic pleural cavities are large and aggressive interventions such as thoracic windows or pleural drainage. In fact, since the beginning of the 20th century, we have been trying to fill chronic pleural cavities with various substances such as air, oils, paraffin and silicones unsuccessfully. Today, thanks to these innovative polyurethane foams with self-expanding and self-molding features, "we would avoid large surgeries with a single orifice and the mixing of two liquid substances,"  as José Miguel Martín and Carlos Rombolá reported.

Further information on this technology: “New self-expanding foams for filling pleural cavities” / Video


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Images of polyurethane foams and chemicals from the UA Adhesion and Adhesives Lab, Alfonso de Lucas Freile and José Miguel Martín Martínez Author: Roberto Ruiz

Photo of the Albacete University Hospital Complex of Albacete medical team: Mercedes Cambronero Aroca; Marta Genoves Crespo; Carlos A. Rombola; Monica Gómez-Juarez Sango. Author: Albacete University Hospital Complex

SEM micrographs at 40x magnification of polyurethane foam Images courtesy of the UA Adhesion and Adhesives Lab



Voice clip of UA Adhesion and Adhesives Lab Professor of Inorganic Chemistry Jose Miguel Martin Martinez


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